Multiple Roles for Hepatitis B and C Viruses and the Host in the Development of Hepatocellular Carcinoma
- 6 November 2020
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Hepatology
- Vol. 73 (S1), 27-37
- https://doi.org/10.1002/hep.31481
Abstract
Chronic hepatitis B and C are major risk factors for hepatocellular carcinoma (HCC) in the United States and worldwide. Direct and indirect mechanisms of viral infection lead to the development of HCC. Chronic viral infection leads to inflammation and liver damage, culminating in cirrhosis, the penultimate step in the progression toward HCC. Host, viral, and environmental factors likely interact to promote oncogenesis. Clinical considerations include recommendations for screening for HCC in persons at risk, treatment with antivirals, and an emerging role for immunotherapy. We pose unanswered questions regarding HCC susceptibility and pathogenesis in the setting of chronic hepatitis B and C.Funding Information
- Health Services Research and Development
- National Institute of Diabetes and Digestive and Kidney Diseases (K08‐DK106478)
This publication has 106 references indexed in Scilit:
- A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus InfectionPLOS ONE, 2013
- MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesisJCI Insight, 2012
- Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis BProceedings of the National Academy of Sciences of the United States of America, 2012
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in CancerThe New England Journal of Medicine, 2012
- Family history of liver cancer and hepatocellular carcinomaJournal of Hepatology, 2011
- T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced LeukemiaScience Translational Medicine, 2011
- Hepatitis C Virus Regulates Transforming Growth Factor β1 Production Through the Generation of Reactive Oxygen Species in a Nuclear Factor κB–Dependent MannerGastroenterology, 2010
- Downregulation of Gadd45 beta Expression by Hepatitis C Virus Leads to Defective Cell Cycle ArrestCancer Research, 2010
- The association of family history of liver cancer with hepatocellular carcinoma: A case-control study in the United StatesJournal of Hepatology, 2009
- HCV, Iron, and Oxidative Stress: The New Choreography of HepcidinGastroenterology, 2008