Risk‐based, response‐adapted therapy for early‐stage extranodal nasal‐type NK/T‐cell lymphoma in the modern chemotherapy era: A China Lymphoma Collaborative Group study
- 25 May 2020
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 95 (9), 1047-1056
- https://doi.org/10.1002/ajh.25878
Abstract
We aimed to determine the survival benefits of chemotherapy (CT) additional to radiotherapy (RT) in different risk groups of patients with early‐stage extranodal nasal‐type NK/T‐cell lymphoma (ENKTCL) and to investigate the risk of postponing RT based on induction CT responses. A total of 1360 patients who received RT with or without new‐regimen CT from 20 institutions were retrospectively reviewed. The patients had received RT alone, RT followed by CT (RT+CT), or CT followed by RT (CT+RT). The patients were stratified into different risk groups using the nomogram‐revised risk index (NRI). A comparative study was performed using propensity score‐matched (PSM) analysis. Adding new‐regimen CT to RT (versus RT alone) significantly improved overall survival (OS, 73.2% vs. 60.9%, P < 0.001) and progression‐free survival (PFS, 63.5% vs. 54.2%, P < 0.001) for intermediate‐/high‐risk patients, but not for low‐risk patients. For intermediate‐/high‐risk patients, RT+CT and CT+RT resulted in non‐significantly different OS (77.7% vs. 72.4%; P = 0.290) and PFS (67.1% vs. 63.1%; P = 0.592). For patients with complete response (CR) after induction CT, initiation of RT within or beyond three cycles of CT resulted in similar OS (78.2% vs. 81.7%, P = 0.915) and PFS (68.2% vs. 69.9%, P = 0.519). For patients without CR, early RT resulted in better PFS (63.4% vs. 47.6%, P = 0.019) than late RT. Risk‐based, response‐adapted therapy involving early RT combined with CT is a viable, effective strategy for intermediate‐/high‐risk early‐stage patients with ENKTCL in the modern treatment era.Keywords
Funding Information
- Research and Development
This publication has 41 references indexed in Scilit:
- Burden of lymphoma in China, 2006–2016: an analysis of the Global Burden of Disease Study 2016Journal of Hematology & Oncology, 2019
- Mortality of lymphoma and myeloma in China, 2004–2017: an observational studyJournal of Hematology & Oncology, 2019
- The impact of the omission or inadequate dosing of radiotherapy in extranodal natural killer T‐cell lymphoma, nasal type, in the United StatesCancer, 2017
- Association of Improved Locoregional Control With Prolonged Survival in Early-Stage Extranodal Nasal-Type Natural Killer/T-Cell LymphomaJAMA Oncology, 2017
- Risk-adapted therapy for early-stage extranodal nasal-type NK/T-cell lymphoma: analysis from a multicenter studyBlood, 2015
- Immunophenotypic and Clinical Differences Between the Nasal and Extranasal Subtypes of Upper Aerodigestive Tract Natural Killer/T-Cell LymphomaInternational Journal of Radiation Oncology*Biology*Physics, 2014
- Radiotherapy Alone With Curative Intent in Patients With Stage I Extranodal Nasal-Type NK/T-Cell LymphomaInternational Journal of Radiation Oncology*Biology*Physics, 2012
- Failure patterns and clinical implications in early stage nasal natural killer/T‐cell lymphoma treated with primary radiotherapyCancer, 2011
- International Peripheral T-Cell and Natural Killer/T-Cell Lymphoma Study: Pathology Findings and Clinical OutcomesJournal of Clinical Oncology, 2008
- Radiotherapy As Primary Treatment for Stage IE and IIE Nasal Natural Killer/T-Cell LymphomaJournal of Clinical Oncology, 2006