The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions
Open Access
- 15 January 2021
- Vol. 10 (1), 167
- https://doi.org/10.3390/cells10010167
Abstract
Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in IRES allowed the identification of a multitude of potential molecular targets. Among the most promising, G Protein Coupled Receptor Kinase type 2 (GRK2) appears to be a suitable one given its functional implications in many cellular processes. In this review, we will discuss the metabolic role of GRK2 in those conditions that are characterized by insulin resistance (diabetes, hypertension, heart failure), and the potentiality of its inhibition as a therapeutic strategy to revert both insulin resistance and its associated phenotypes.This publication has 118 references indexed in Scilit:
- Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesisCellular Signalling, 2012
- The complex G protein‐coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targetsBritish Journal of Pharmacology, 2010
- Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic OpportunitiesAntioxidants and Redox Signaling, 2010
- Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetesCurrent Opinion in Lipidology, 2010
- Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylationCurrent Opinion in Pharmacology, 2009
- The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBαProceedings of the National Academy of Sciences of the United States of America, 2008
- Energy metabolism in heart failure and remodellingCardiovascular Research, 2008
- Inflammation and insulin resistanceFEBS Letters, 2007
- Mechanisms linking obesity to insulin resistance and type 2 diabetesNature, 2006
- Diabetes, oxidative stress, and antioxidants: A reviewJournal of Biochemical and Molecular Toxicology, 2003