Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators
- 15 February 2020
- journal article
- research article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 30 (4), 126852
- https://doi.org/10.1016/j.bmcl.2019.126852
Abstract
No abstract availableThis publication has 21 references indexed in Scilit:
- Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanismBioorganic & Medicinal Chemistry, 2013
- Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseasesJournal of Neural Transmission, 2012
- Proteomic Analysis Shows Synthetic Oleanane Triterpenoid Binds to mTORPLOS ONE, 2011
- Oxidative damage in multiple sclerosis lesionsBrain, 2011
- Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathwayBrain, 2011
- Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 ActivityMolecular and Cellular Biology, 2008
- Involvement of Oxidative Stress in Alzheimer DiseaseJournal of Neuropathology and Experimental Neurology, 2006
- Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2Molecular and Cellular Biology, 2004
- Rhodium-Catalyzed Conjugate Addition of Aryl- or 1-Alkenylboronic Acids to EnonesOrganometallics, 1997
- Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.Proceedings of the National Academy of Sciences of the United States of America, 1994