Contralateral Eye Involvement and Retinal Detachment in Patients with Cytomegalovirus Retinitis Treated with Intravitreous Ganciclovir
- 10 April 2020
- journal article
- research article
- Published by Taylor & Francis Ltd in Ocular Immunology and Inflammation
- Vol. 29 (6), 1145-1150
- https://doi.org/10.1080/09273948.2020.1728344
Abstract
Purpose: To determine the incidence of contralateral eye involvement and retinal detachment in HIV-infected patients with cytomegalovirus retinitis treated with repeated intravitreous ganciclovir. Methods: In a prospective cohort study in Northern Thailand, HIV-infected patients with cytomegalovirus retinitis were treated with antiretroviral therapy and intravitreous ganciclovir injections and followed for 3 months for contralateral cytomegalovirus retinitis and retinal detachment. Results: Of 49 participants with unilateral cytomegalovirus retinitis at enrollment, 7 developed contralateral eye involvement (4.8/100 person-months, 95% CI 1.9–9.8). Of 105 eyes without a retinal detachment at enrollment, 6 developed a retinal detachment (2.0/100 eye-months, 95% CI 0.7–4.3). Baseline clinical factors were not associated with the development of either outcome. Conclusion: Eyes treated with intravitreous ganciclovir experienced retinal detachment at a rate similar to other populations treated with systemic antivirals. The risk of contralateral eye involvement was relatively high during the first 3 months after initial diagnosis despite the institution of antiretroviral therapy.Keywords
Funding Information
- Doris Duke Charitable Foundation (None)
- Harper-Inglis Memorial for Eye Research, The Peierls Foundation, That Man May See, and Research to Prevent Blindness (None)
- Fortisure Founation (None)
- JaMel and Tom Perkins Family Foundation (None)
- That Man May See (None)
This publication has 26 references indexed in Scilit:
- Cytomegalovirus Retinitis in Patients With Acquired Immunodeficiency Syndrome After Initiating Antiretroviral TherapyAmerican Journal of Ophthalmology, 2016
- Risk factors for CMV retinitis among individuals with HIV and low CD4 count in northern Thailand: importance of access to healthcareBritish Journal of Ophthalmology, 2016
- Characteristics of Untreated AIDS-related Cytomegalovirus Retinitis. II. Findings in the Era of Highly Active Antiretroviral Therapy (1997 to 2000)American Journal of Ophthalmology, 2008
- Cytomegalovirus Retinitis: The Neglected Disease of the AIDS PandemicPLoS Medicine, 2007
- Longitudinal Study of the Ocular Complications of AIDS: 1. Ocular Diagnoses at EnrollmentOphthalmology, 2007
- Incidence of and Risk Factors for Visual Acuity Loss among Patients with AIDS and Cytomegalovirus Retinitis in the Era of Highly Active Antiretroviral TherapyOphthalmology, 2006
- Natural History and Outcome of New AIDS-Related Cytomegalovirus Retinitis Diagnosed in the Era of Highly Active Antiretroviral TherapyClinical Infectious Diseases, 2000
- Opportunistic infections occurring during highly active antiretroviral treatmentAIDS, 1998
- Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus InfectionThe New England Journal of Medicine, 1998
- Incidence and Natural History of Cytomegalovirus Disease in Patients with Advanced Human Immunodeficiency Virus Disease Treated with ZidovudineThe Journal of Infectious Diseases, 1992