Prognostic significance of systemic inflammation score in patients who undergo hepatic resection for hepatocellular carcinoma
- 17 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Langenbecks Archiv für Chirurgie
- Vol. 406 (3), 773-779
- https://doi.org/10.1007/s00423-021-02103-1
Abstract
Purpose Systemic inflammation score (SIS) is a novel prognostic score (0, 1, or 2) for various cancers, based on preoperative serum albumin level and lymphocyte-to-monocyte ratio (LMR); modified SIS (mSIS) uses a different LMR cutoff value and was thought to be a more accurate predictor for cancer prognosis. Here, we assessed the prognostic value of SIS and mSIS in patients who receive hepatic resection for hepatocellular carcinoma (HCC). Methods We retrospectively evaluated SIS and mSIS of 314 patients after hepatic resection for HCC, against their clinicopathological factors and outcomes, using receiver operating characteristics (ROC) analysis over time. Results Among patients with preoperative SIS 2, significantly more HCC specimens were poorly differentiated (P = 0.0281), larger (P = 0.0006), and had more microscopic vascular invasion (P = 0.0136) than the SIS 0–1 group; the mSIS 2 group also had significantly larger tumors (P = 0.0039) than the mSIS 0–1 group. In ROC analysis, SIS was a better predictor of overall survival (OS) and recurrence-free survival (RFS) than mSIS. The SIS 2 group had shorter OS (P = 0.0015) and RFS (P = 0.0065) than other patients. In multivariate analysis, SIS 2 was an independent risk factor for shorter OS (hazard ratio (HR) 1.53, P = 0.0497) and RFS (HR 1.58, P = 0.0053). Conclusion SIS is superior to mSIS in predicting prognosis of patients with HCC. mSIS is not a great predictor of prognosis in resected HCC.Funding Information
- Japan Society for the Promotion of Science (JP-19K09198)
This publication has 26 references indexed in Scilit:
- Systemic inflammation score predicts postoperative prognosis of patients with clear-cell renal cell carcinomaBritish Journal of Cancer, 2015
- Low preoperative lymphocyte-monocyte ratio (LMR) represents a potentially poor prognostic factor in nonmetastatic clear cell renal cell carcinomaUrologic Oncology, 2014
- Impact of Histologically Confirmed Lymph Node Metastases on Patient Survival After Surgical Resection for Hepatocellular CarcinomaAnnals of Surgery, 2014
- Preoperative Neutrophil-to-Lymphocyte Ratio Is a Predictor of Survival After Hepatectomy for Hepatocellular CarcinomaAnnals of Surgery, 2013
- Zero mortality in more than 300 hepatic resections: validity of preoperative volumetric analysisSurgery Today, 2011
- Systemic inflammation, nutritional status and survival in patients with cancerCurrent Opinion in Clinical Nutrition and Metabolic Care, 2009
- Trophic macrophages in development and diseaseNature Reviews Immunology, 2009
- Inflaming metastasisNature, 2008
- Cancer-related inflammationNature, 2008
- Inflammation and cancer: back to Virchow?The Lancet, 2001