DrosophilaMyoblast Fusion: Invasion and Resistance for the Ultimate Union
- 3 December 2019
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 53 (1), 67-91
- https://doi.org/10.1146/annurev-genet-120116-024603
Abstract
Cell–cell fusion is indispensable for creating life and building syncytial tissues and organs. Ever since the discovery of cell–cell fusion, how cells join together to form zygotes and multinucleated syncytia has remained a fundamental question in cell and developmental biology. In the past two decades, Drosophila myoblast fusion has been used as a powerful genetic model to unravel mechanisms underlying cell–cell fusion in vivo. Many evolutionarily conserved fusion-promoting factors have been identified and so has a surprising and conserved cellular mechanism. In this review, we revisit key findings in Drosophila myoblast fusion and highlight the critical roles of cellular invasion and resistance in driving cell membrane fusion. Expected final online publication date for the Annual Review of Genetics Volume 53 is November 25, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.Keywords
This publication has 115 references indexed in Scilit:
- Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusionNature, 2013
- Phosphatidylserine directly and positively regulates fusion of myoblasts into myotubesBiochemical and Biophysical Research Communications, 2011
- Competition between Blown Fuse and WASP for WIP Binding Regulates the Dynamics of WASP-Dependent Actin Polymerization In VivoDevelopmental Cell, 2011
- A genome-scale shRNA resource for transgenic RNAi in DrosophilaNature Methods, 2011
- The SCAR and WASp nucleation‐promoting factors act sequentially to mediate Drosophila myoblast fusionEMBO Reports, 2009
- Directed, efficient, and versatile modifications of the Drosophila genome by genomic engineeringProceedings of the National Academy of Sciences of the United States of America, 2009
- Drosophila ELMO/CED-12 interacts with Myoblast city to direct myoblast fusion and ommatidial organizationDevelopmental Biology, 2008
- The MARVEL domain protein, Singles Bar, is required for progression past the pre-fusion complex stage of myoblast fusionDevelopmental Biology, 2007
- A genome-wide transgenic RNAi library for conditional gene inactivation in DrosophilaNature, 2007
- Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complexNature, 2002