Advancement of Natural Compounds as Anti-rheumatoid Arthritis Agents: A Focus on Their Mechanism of Actions
- 1 November 2021
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Mini-Reviews in Medicinal Chemistry
- Vol. 21 (19), 2957-2975
- https://doi.org/10.2174/1389557521666210304112916
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease categorized by infiltration of inflammatory cells, synovial hyperplasia, pannus formation and bone destruction, leading to disability worldwide. Despite the presence of the commercial availability of anti-RA agent on the market, the application of these drugs is limited due to its side effects. Anti-rheumatic drugs are more effective and safer being investigated by many researchers, especially, natural products with anti-RA have been identified and the underlying molecular mechanisms of action of novel and known compounds have been reported. In this review, we intend to provide a comprehensive view and updated on naturally occurring compounds known and novel that has the effect of anti-RA, and then classify them according to their molecular mechanisms of action in regulating the anti-RA lane main. The safety of compounds from natural plants and western medicine has also been briefly compared. In addition, the clinical trials with anti-RA compounds isolated from natural plants in RA were also summarized in this manuscript.Keywords
Funding Information
- Natural Science Foundation of China (81703819, 81874369, 82074122)
- Ministry of Science and Technology of the People's Republic of China (2018YFC1707902, 2018FY100703)
- Hunan Provincial Science and Technology Department (2018WK2081, 2018SK2110)
- Hunan Provincial Innovation Foundation for Postgraduate (CX2018B476)
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