Traditional and Non-traditional Risk Factors for Osteoporosis in CKD
- 14 February 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Calcified Tissue International
- Vol. 108 (4), 496-511
- https://doi.org/10.1007/s00223-020-00786-0
Abstract
Osteoporosis is a state of bone fragility with reduced skeletal resistance to trauma, and consequently increased risk of fracture. A wide range of conditions, including traditional risk factors, lifestyle choices, diseases and their treatments may contribute to bone fragility. It is therefore not surprising that the multi-morbid patient with chronic kidney disease (CKD) is at a particularly high risk. CKD is associated with reduced bone quantity, as well as impaired bone quality. Bone fragility in CKD is a composite of primary osteoporosis, accumulation of traditional and uremia-related risk factors, assaults brought on by systemic disease, and detrimental effects of drugs. Some risk factors are modifiable and represent potential targets for intervention. This review provides an overview of the heterogeneity of bone fragility in CKD.Keywords
Funding Information
- European Renal Association (Long-term fellowship)
- Flemish Fund for Scientific Research (1196520N)
- Kidney Research UK
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