The Prognostic Values of PARP-1 Expression in Uveal Melanoma
Open Access
- 31 January 2021
- Vol. 10 (2), 285
- https://doi.org/10.3390/cells10020285
Abstract
Background: Uveal melanoma is the most common primary intraocular malignancy in adults. In advanced cases, the prognosis is very poor. Thus far, no effective methods of pharmacotherapy of this cancer have been found. The aim of the study was to evaluate the expression of PARP-1, the best-known member of the family of poly(ADP-ribose) polymerases, in uveal melanoma and its associations with clinicopathological parameters, overall survival, and disease-free survival. Methods: The study included 91 patients who underwent enucleation due to uveal melanoma. PARP-1 expression was assessed by immunohistochemistry. Results: High PARP-1 expression was associated with more frequent chromosome 3 loss, higher histopathological grade, bigger tumor size, and absence of intrascleral extension. High PARP-1 expression was associated with shorter overall survival time and disease-free survival time. Conclusions: The above findings indicate that high expression of PARP-1 can be considered as an unfavorable prognostic factor in uveal melanoma.Keywords
Funding Information
- Polish Minister of Science and Higher Education (SUB.B130.20.022)
This publication has 40 references indexed in Scilit:
- Altered Expression of the Poly(ADP-Ribosyl)ation Enzymes in Uveal Melanoma and Regulation ofPARGGene Expression by the Transcription Factor ERMInvestigative Ophthalmology & Visual Science, 2012
- Overexpression of chromatin assembly factor‐1 p60, poly(ADP‐ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancerHistopathology, 2012
- Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancerAnnals of Oncology, 2011
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cellsProceedings of the National Academy of Sciences of the United States of America, 2011
- Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor TypesGenes & Cancer, 2010
- Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1Science, 2009
- A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activationNature Structural & Molecular Biology, 2009
- PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinomaCarcinogenesis: Integrative Cancer Research, 2008
- Crosstalk between PARP-1 and NF-κB modulates the promotion of skin neoplasiaOncogene, 2004