A Nationwide Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in Greece: Inference of the Molecular Transmission Clusters
Open Access
- 19 October 2020
- Vol. 12 (10), 1183
- https://doi.org/10.3390/v12101183
Abstract
Our aim was to investigate the dispersal patterns and parameters associated with local molecular transmission clusters (MTCs) of subtypes A1 and B in Greece (predominant HIV-1 subtypes). The analysis focused on 1751 (28.4%) and 2575 (41.8%) sequences of subtype A1 and B, respectively. Identification of MTCs was based on phylogenetic analysis. The analyses identified 38 MTCs including 2–1518 subtype A1 sequences and 168 MTCs in the range of 2–218 subtype B sequences. The proportion of sequences within MTCs was 93.8% (1642/1751) and 77.0% (1982/2575) for subtype A1 and B, respectively. Transmissions within MTCs for subtype A1 were associated with risk group (Men having Sex with Men vs. heterosexuals, OR = 5.34, p < 0.001) and Greek origin (Greek vs. non-Greek origin, OR = 6.05, p < 0.001) and for subtype B, they were associated with Greek origin (Greek vs. non-Greek origin, OR = 1.57, p = 0.019), younger age (OR = 0.96, p < 0.001), and more recent sampling (time period: 2011–2015 vs. 1999–2005, OR = 3.83, p < 0.001). Our findings about the patterns of across and within country dispersal as well as the parameters associated with transmission within MTCs provide a framework for the application of the study of molecular clusters for HIV prevention.Keywords
Funding Information
- Gilead Sciences (4205/22-01-2018)
This publication has 55 references indexed in Scilit:
- HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemicsRetrovirology, 2013
- Characterizing HIV Transmission Networks Across the United StatesClinical Infectious Diseases, 2012
- MrBayes 3.2: Efficient Bayesian Phylogenetic Inference and Model Choice Across a Large Model SpaceSystematic Biology, 2012
- BEAGLE: An Application Programming Interface and High-Performance Computing Library for Statistical PhylogeneticsSystematic Biology, 2011
- Molecular and epidemiological characterization of HIV-1 infection networks involving transmitted drug resistance mutations in Northern GreeceJournal of Antimicrobial Chemotherapy, 2011
- FastTree 2 – Approximately Maximum-Likelihood Trees for Large AlignmentsPLOS ONE, 2010
- Episodic Sexual Transmission of HIV Revealed by Molecular PhylodynamicsPLoS Medicine, 2008
- New Insights into the Origin of the HIV Type 1 Subtype A Epidemic in Former Soviet Union's Countries Derived from Sequence Analyses of Preepidemically Transmitted VirusesAIDS Research and Human Retroviruses, 2007
- Increasing Prevalence of HIV‐1 Subtype A in Greece: Estimating Epidemic History and OriginThe Journal of Infectious Diseases, 2007
- Molecular Diversity of HIV in AlbaniaThe Journal of Infectious Diseases, 2005