Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption
- 9 July 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in Environmental Science & Technology
- Vol. 54 (14), 8491-8499
- https://doi.org/10.1021/acs.est.9b07205
Abstract
A growing number of environmental pollutants are known to adversely affect the thyroid hormone system, and major gaps have been identified in the tools available for the identification, and the hazard and risk assessment of these thyroid hormone disrupting chemicals. We provide an example of how the adverse outcome pathway (AOP) framework and associated data generation can address current testing challenges in the context of fish early life stage tests, and fish tests in general. We demonstrate how a suite of assays covering biological processes involved in the underlying toxicological pathways can be implemented in a tiered screening and testing approach for thyroid hormone disruption, using the levels of assessment of the OECD’s Conceptual Framework for the Testing and Assessment of Endocrine Disrupting Chemicals as a guide.Keywords
Funding Information
- Procter and Gamble
- Universiteit Antwerpen (ID 3880)
- Fonds Wetenschappelijk Onderzoek (G051117N)
- European Chemical Industry Council (LRI-ECO20.2-UA)
- Horizon 2020 Framework Programme (825753)
- Society of Environmental Toxicology and Chemistry
- European Centre for Ecotoxicology and Toxicology of Chemicals
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