Conjunctival Injection Reduction in Patients with Atopic Keratoconjunctivitis Due to Synergic Effect of Bovine Enteric-Coated Lactoferrin in 0.1% Tacrolimus Ophthalmic Suspension
Open Access
- 24 September 2020
- journal article
- research article
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 9 (10), 3093
- https://doi.org/10.3390/jcm9103093
Abstract
Lactoferrin (LF), a multifunctional glycoprotein found in mammalian milk, is reported to have immunoregulatory effects. The present study aimed to evaluate whether enteric-coated LF (eLF) could improve symptoms in patients with atopic keratoconjunctivitis (AKC). This randomized double-blind placebo-controlled single-center trial comprised Japanese patients (n = 20; aged 22–60 years) with AKC. Patients treated with 0.1% tacrolimus ophthalmic suspension (TALYMUS®) were administered eLF (400 mg/d of bovine LF) or placebo tablets for 12 weeks. Conjunctival injection was examined, papillae formation in the palpebral conjunctiva was evaluated, and corneal fluorescein score, itchy sensation in end-point itching scale, and serum allergic parameters were assessed. Conjunctival injection was significantly reduced in the LF group than in the placebo group (p = 0.0017, Mann–Whitney U-test). Papillae formation in the palpebral conjunctiva showed a statistical decrease in the LF group than in the placebo group (p = 0.010, unpaired T-test). LF combined with TALYMUS® could be a promising treatment strategy to mitigate AKC.This publication has 39 references indexed in Scilit:
- Bovine Lactoferrin Counteracts Toll-Like Receptor Mediated Activation Signals in Antigen Presenting CellsPLOS ONE, 2011
- Effects of pepsin and trypsin on the anti-adipogenic action of lactoferrin against pre-adipocytes derived from rat mesenteric fatBritish Journal of Nutrition, 2010
- A Randomized, Placebo-Controlled Clinical Trial of Tacrolimus Ophthalmic Suspension 0.1% in Severe Allergic ConjunctivitisJournal of Ocular Pharmacology and Therapeutics, 2010
- A critical review of the roles of host lactoferrin in immunityBioMetals, 2010
- Effect of Orally Administered Bovine Lactoferrin on the Growth of Adenomatous Colorectal Polyps in a Randomized, Placebo-Controlled Clinical TrialCancer Prevention Research, 2009
- Immunomodulatory effects of lactoferrin on antigen presenting cellsBiochimie, 2009
- Proactive disease management with 0·03% tacrolimus ointment for children with atopic dermatitis: results of a randomized, multicentre, comparative studyBritish Journal of Dermatology, 2008
- Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cellsThe FASEB Journal, 2008
- Management of Severe Allergic Conjunctivitis With Topical Cyclosporin A 0.05% EyedropsCornea, 2007
- Mg Segregation atHeterophase Interfaces on an Atomic Scale: Experiments and ComputationsPhysical Review Letters, 2003