Have incidence rates of liver cancer peaked in the United States?
- 15 April 2020
- Vol. 126 (13), 3151-3155
- https://doi.org/10.1002/cncr.32794
Abstract
Background Liver cancer incidence has increased for several decades in the United States. Recently, reports have suggested that rates of hepatocellular carcinoma (HCC), the dominant form of liver cancer, had declined in certain groups. However, to the authors' knowledge, the most recent histology‐specific liver cancer rates have not been reported to date. Methods The authors examined the incidence of HCC and intrahepatic cholangiocarcinoma (ICC) from 1992 through 2016 using data from the Surveillance, Epidemiology, and End Results registries. Age‐standardized incidence rates were calculated by histology, sex, race and/or ethnicity, and age. Trends were analyzed using the National Cancer Institute's Joinpoint Regression Program to estimate the annual percent change. Results Between 2011 and 2016, HCC rates significantly declined (annual percent change, −1.9%), with more prominent declines noted among males, Asian/Pacific Islanders, and individuals aged <50 years. Conversely, ICC rates increased from 2002 through 2016. Conclusions Declining HCC rates may persist due to improved treatment of the hepatitis C virus and/or competing causes of mortality among individuals with fatty liver disease.Keywords
Funding Information
- National Cancer Institute (Intramural Funding)
This publication has 29 references indexed in Scilit:
- Nonalcoholic Fatty Liver DiseaseJAMA, 2015
- Changing Hepatocellular Carcinoma Incidence and Liver Cancer Mortality Rates in the United StatesThe American Journal of Gastroenterology, 2014
- The changing epidemiology of hepatitis C virus infection in the United States: National health and nutrition examination survey 2001 through 2010Journal of Hepatology, 2014
- Gender and racial differences in nonalcoholic fatty liver diseaseWorld Journal of Hepatology, 2014
- Non-alcoholic fatty liver disease and mortality among US adults: prospective cohort studyBMJ, 2011
- Risk factors for cholangiocarcinomaJournal of Hepatology, 2011
- Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease ProgressionGastroenterology, 2010
- Hepatocellular Carcinoma Incidence, Mortality, and Survival Trends in the United States From 1975 to 2005Journal of Clinical Oncology, 2009
- Risk factors for intrahepatic cholangiocarcinoma: A case-control study in ChinaWorld Journal of Gastroenterology, 2008
- A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decadesProceedings of the National Academy of Sciences of the United States of America, 2002