Background: Reno-vascular disease is a complex disorder, the most common cause of which is RAS. Multi detector computed tomography angiography (MDCTA) plays an important role in assessment of the renal vasculature. Despite conventional angiography is still considered the gold standard in reno-vascular imaging, MDCTA is increasingly used as it is less invasive, easily applicable and available. Aim of the Study: In our study we aimed to assess the role of CT Angiography in diagnosis of renal vasculature abnormalities. Patients and Methods: This prospective study was carried out at The Radio-diagnosis and Medical Imaging Department in our institute, conducted on 40 Patients who are clinically suspected to have reno-vascular abnormalities in the period from September 2018 to February 2021. Their ages ranged from 33 to 56 years old. Results: Based on CTA findings, out of 40 patients, 6 (15%) patients were confirmed to have accessory renal arteries, 6 (15%) patients had renal artery aneurysm, 6 (15%) patients had nutcracker syndrome, 6 (15%) patients had dual venous drainage of both kidneys, two of them showed retro-aortic left renal vein &10 (25%) patients were confirmed to have renal artery stenosis. Conclusion: CT Angiography with multiplanar reconstruction and three-dimensional display is valuable in studying patients with reno-vascular lesions involving the proximal renal vessels. MDCT angiography is advantageous being a non-invasive technique that can be done on outpatient basis without pre or post-procedure admission, no special post-procedure care and less cost.