Temporal clustering, tissue composition, and total variation for mapping oxygen extraction fraction using QSM and quantitative BOLD
- 10 June 2021
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 86 (5), 2635-2646
- https://doi.org/10.1002/mrm.28875
Abstract
Purpose To improve the accuracy of quantitative susceptibility mapping plus quantitative blood oxygen level-dependent magnitude (QSM+qBOLD or QQ) based mapping of oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) using temporal clustering, tissue composition, and total variation (CCTV). Methods Three-dimensional multi-echo gradient echo and arterial spin labeling images were acquired from 11 healthy subjects and 33 ischemic stroke patients. Diffusion-weighted imaging (DWI) was also obtained from patients. The CCTV mapping was developed for incorporating tissue-type information into clustering of the previous cluster analysis of time evolution (CAT) and applying total variation (TV). The QQ-based OEF and CMRO2 were reconstructed with CAT, CAT+TV (CATV), and the proposed CCTV, and results were compared using region-of-interest analysis, Kruskal-Wallis test, and post hoc Wilcoxson rank sum test. Results In simulation, CCTV provided more accurate and precise OEF than CAT or CATV. In healthy subjects, QQ-based OEF was less noisy and more uniform with CCTV than CAT. In subacute stroke patients, OEF with CCTV had a greater contrast-to-noise ratio between DWI-defined lesions and the unaffected contralateral side than with CAT or CATV: 1.9 ± 1.3 versus 1.1 ± 0.7 (P = .01) versus 0.7 ± 0.5 (P < .001). Conclusion The CCTV mapping significantly improves the robustness of QQ-based OEF against noise.Funding Information
- National Institutes of Health (R01NS090464, R01NS095562, R21AG067466, S10OD021782, R01NS105144, K99NS123229)
This publication has 86 references indexed in Scilit:
- Morphology enabled dipole inversion for quantitative susceptibility mapping using structural consistency between the magnitude image and the susceptibility mapNeuroImage, 2012
- Phase‐based regional oxygen metabolism (PROM) using MRIMagnetic Resonance in Medicine, 2011
- QUantitative Imaging of eXtraction of oxygen and TIssue consumption (QUIXOTIC) using venular‐targeted velocity‐selective spin labelingMagnetic Resonance in Medicine, 2011
- A novel background field removal method for MRI using projection onto dipole fields (PDF)NMR in Biomedicine, 2011
- MRI Estimation of Global Brain Oxygen Consumption RateJournal of Cerebral Blood Flow & Metabolism, 2010
- Continuous flow‐driven inversion for arterial spin labeling using pulsed radio frequency and gradient fieldsMagnetic Resonance in Medicine, 2008
- Validation of oxygen extraction fraction measurement by qBOLD techniqueMagnetic Resonance in Medicine, 2008
- Suppression of MRI Truncation Artifacts Using Total Variation Constrained Data ExtrapolationInternational Journal of Biomedical Imaging, 2008
- Quantitative evaluation of oxygenation in venous vessels using T2‐Relaxation‐Under‐Spin‐Tagging MRIMagnetic Resonance in Medicine, 2008
- Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expressionProceedings of the National Academy of Sciences of the United States of America, 2006