International BEAT-PCD Consensus Statement for Infection Prevention and Control for Primary Ciliary Dyskinesia in collaboration with ERN-LUNG PCD Core NETWORK and patient representatives
Open Access
- 11 June 2021
- journal article
- research article
- Published by European Respiratory Society (ERS) in ERJ Open Research
Abstract
Introduction In primary ciliary dyskinesia (PCD) impaired mucociliary clearance leads to recurrent airway infections and progressive lung destruction, and concern over chronic airway infection and patient-to-patient transmission is considerable. So far, there has been no defined consensus on how to control infection across centres caring for patients with PCD. Within the BEAT-PCD Network, COST Action and ERS CRC together with the ERN-Lung PCD core a first initiative was now taken towards creating such consensus statement. Methods A multidisciplinary international PCD expert panel was set up to create a consensus statement for infection prevention and control (IP&C) for PCD, covering diagnostic microbiology, infection prevention for specific pathogens considered indicated for treatment, and segregation aspects. Using a modified Delphi process, consensus to a statement demanded at least 80% agreement within the PCD expert panel group. Patient organisation representatives were involved throughout the process. Results We present a consensus statement on 20 IP&C statements for PCD including suggested actions for microbiological identification, indications for treatment of Pseudomonas aeruginosa, Burkholderia cepacia and nontuberculous mycobacteria and suggested segregation aspects aimed to minimise patient-to-patient transmission of infections whether in-hospital, in PCD clinics or wards, or out of hospital at meetings between people with PCD. The statement also includes segregation aspects adapted to the current COVID-19 pandemic. Conclusion The first ever international consensus statement on IP&C intended specifically for PCD is presented and is targeted clinicians managing paediatric and adult patients with PCD, microbiologists, patient organisations and not least the patients and their families.Keywords
Funding Information
- Ministerstvo Zdravotnictví Ceské Republiky (grant nr. NV-19-07-00210.)
- European Reference Network for Rare Respiratory Diseases (Project ID No 739546.)
- Børnelungefonden
- European Cooperation in Science and Technology (COST Action BM 1407)
- Danmarks Lungeforening
- European Respiratory Society (CRC)
This publication has 53 references indexed in Scilit:
- Multicenter analysis of body mass index, lung function, and sputum microbiology in primary ciliary dyskinesiaPediatric Pulmonology, 2014
- Stenotrophomonas maltophiliaCurrent Opinion in Pulmonary Medicine, 2012
- Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosisJournal of Cystic Fibrosis, 2011
- Primary ciliary dyskinesia: a consensus statement on diagnostic and treatment approaches in childrenEuropean Respiratory Journal, 2009
- The World Health Organization Guidelines on Hand Hygiene in Health Care and Their Consensus RecommendationsInfection Control & Hospital Epidemiology, 2009
- Primary Ciliary DyskinesiaAmerican Journal of Respiratory and Critical Care Medicine, 2004
- Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patientsJournal of Cystic Fibrosis, 2003
- An epidemic spread of multiresistant Pseudomonas aeruginosa in a cystic fibrosis centreJournal of Antimicrobial Chemotherapy, 1986
- Absence of axonemal arms in nasal mucosa cilia in Kartagener's syndromeNature, 1976
- A Human Syndrome Caused by Immotile CiliaScience, 1976