Triglyceride–glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal study
Open Access
- 24 July 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Endocrine Disorders
- Vol. 20 (1), 1-7
- https://doi.org/10.1186/s12902-020-00581-w
Abstract
Colorectal cancer (CRC), which is related with insulin resistance, is a one of the most common cancers. Triglyceride-glucose index (TyG index) was made for a marker of insulin resistance. We conducted the investigation of association between TyG index and incident CRC. We examined the affect of TyG index on incident CRC in this historical cohort study of 27,944 (16,454 men and 11,490 women) participants. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. The impact of TyG index on incident CRC was investigated using Cox proportional hazard models, adjusting for sex, age, body mass index, smoking status, alcohol consumption, exercise, systolic blood pressure and creatinine. The covariate-adjusted receiver operating characteristic (ROC) curve calculated the area under the curve (AUC) and cut-off value of TyG index for the incidence of CRC. During the median 4.4-year follow-up, 116 participants were diagnosed as CRC. The cumulative incidence rate of CRC were 0.4%. In Cox proportional hazard model, the HRs of TyG index were 1.38 (95% Confidence interval (CI), 1.00–1.91, p = 0.049) after adjusting for covariates. In the covariate-adjusted ROC curve analysis, the cut-off value of TyG index for incident CRC was 8.272 (AUC 0.687 (95%CI, 0.637–737, sensitivity = 0.620, specificity = 0.668, p < 0.001)). TyG index can predict the onset of CRC. For early detection of CRC, we should encourage people with high TyG index to undergo screening for CRC.Keywords
This publication has 42 references indexed in Scilit:
- Serum Lipids and the Risk of Gastrointestinal Malignancies in the Swedish AMORIS StudyJournal of Cancer Epidemiology, 2012
- The Association Between IGF-I and Insulin ResistanceDiabetes Care, 2012
- Novel Expression Patterns of PI3K/Akt/mTOR Signaling Pathway Components in Colorectal CancerJournal of the American College of Surgeons, 2010
- Visceral Fat Area and Markers of Insulin Resistance in Relation to Colorectal NeoplasiaDiabetes Care, 2009
- Impact of metabolic factors on subsequent cancer risk: results from a large-scale population-based cohort study in JapanEuropean Journal of Cancer Prevention, 2009
- The Product of Fasting Glucose and Triglycerides As Surrogate for Identifying Insulin Resistance in Apparently Healthy SubjectsMetabolic Syndrome and Related Disorders, 2008
- Remnant lipoproteins stimulate proliferation and activate MAPK and Akt signaling pathways via G protein-coupled receptor in PC-3 prostate cancer cellsClinica Chimica Acta; International Journal of Clinical Chemistry, 2007
- γ-Glutamyltransferase as a Predictor of Chronic Kidney Disease in Nonhypertensive and Nondiabetic Korean MenClinical Chemistry, 2007
- Insulin, Glucose, Insulin Resistance, and Incident Colorectal Cancer in Male SmokersClinical Gastroenterology and Hepatology, 2006
- The PPAR Pro12Ala polymorphism and risk for incident sporadic colorectal adenomasCarcinogenesis: Integrative Cancer Research, 2004