IgG4-Related Pseudotumors Mimicking Metastases in Liver and Lungs
Open Access
- 12 February 2021
- journal article
- review article
- Published by S. Karger AG in Case Reports in Gastroenterology
- Vol. 15 (1), 163-170
- https://doi.org/10.1159/000512410
Abstract
A 47-year-old man complained intermittent dull pain at the right upper quadrant abdomen and right neck swelling for 3 months. Blood tests revealed leukocytosis with mild eosinophilia. Computed tomography (CT) showed the presence of multiple nodules in the liver and both lung fields. Positron emission tomography/CT (PET/CT) scans found increased uptake at lymph nodes of the right neck, in the lung, liver, and prostate. The patient was diagnosed with IgG4-related disease (IgG4-RD) based on the biopsy findings from the right neck lymph nodes, showing enriched IgG4-positive lymphoplasmacytic cells. It is often difficult to distinguish IgG4-RD from malignancy, especially in presentations with multiple pseudotumors. This case serves as a reminder that IgG4-RD should be considered in earlier diagnosis, since pseudotumors in multiple organs may imitate tumor metastases.Keywords
This publication has 19 references indexed in Scilit:
- Significance of peripheral eosinophilia for diagnosis of IgG4-related disease in subjects with elevated serum IgG4 levelsPancreatology, 2020
- Different clinical patterns of IgG4-RD patients with and without eosinophiliaScientific Reports, 2019
- New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 casesArthritis Research & Therapy, 2017
- IgG4‐Related Disease: Clinical and Laboratory Features in One Hundred Twenty‐Five PatientsArthritis & Rheumatology, 2015
- IgG4-Related DiseaseMedicine, 2015
- IgG4-Related DiseaseAnnual Review Of Pathology-Mechanisms Of Disease, 2014
- IgG4-related inflammatory pseudotumors mimicking multiple meningiomasJapanese Journal of Radiology, 2013
- Immunoglobulin G4-related systemic sclerosing disease in a patient with sclerosing cholangitis, inflammatory pseudotumors of the lung and multiple radiological patterns: a case reportClinics, 2011
- Lymphadenopathy of IgG4-related Sclerosing DiseaseThe American Journal of Surgical Pathology, 2008
- Inflammatory Pseudotumors in Multiple Organs Associated with Elevated Serum IgG4 Level: Recovery by Only a Small Replacement Dose of SteroidInternal Medicine, 2008