Long-term Antipsychotic Treatment and Brain Volumes
Top Cited Papers
- 7 February 2011
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 68 (2), 128-137
- https://doi.org/10.1001/archgenpsychiatry.2010.199
Abstract
Schizophrenia, a common mental illness affecting 1% of the worldwide population, remains a leading cause of chronic disability among young adults.1 Antipsychotic medications are the mainstay of treatment because there is strong empirical evidence that these drugs reduce psychotic symptomsand relapse rates in schizophrenia patients.2 Even though the majority of patients receive antipsychotics and benefit from reduction in psychotic symptoms, many patients continue to have negative symptoms, cognitive impairments, and progressive brain tissue loss.3-13 The causes underlying these brain abnormalities are unclear and have been a focus of much debate14,15 and many literature reviews.16,17Keywords
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