In vitro Comparative Study for Anti-proliferative Activity of Some Plant Extracts, Fam. Apiaceae, on HeLa Cell Line
Open Access
- 4 August 2020
- journal article
- research article
- Published by Universitas Gadjah Mada in Indonesian Journal of Pharmacy
- Vol. 31 (2), 108-115
- https://doi.org/10.14499/indonesianjpharm31iss2pp108
Abstract
In this research, the biological activities of five plant extracts from family Apiaceae; Italian Parsley (Petroselinum neapolitanum), Fennel (Foeniculum vulgare), Celery (Apium graveolens), Cilantro (Coriandrum sativum) and Dill (Anethum graveolens), were studied. Antiproliferative effect of eleven ethanol crude extracts was tested in Human Cervical (Hela) cancer cells. Results clearly demonstrated that all plant extracts showed high significant difference when compared to the negative control (DMSO).Parsley leaves extract, cilantro leaves extract and cilantro stems extract showed no significant difference with the positive control (Actinomycin D). As for, fennel bulb extracts, fennel stalks extracts, celery stems gave better results than the positive control with no significant difference through the 24, 48 and 72 h treatment. There were no significant difference between Fennel extracts and the positive control, which showed high effect on the cancer cells survival. There were no significant difference between both extracts of Cilantro leaves and stems through each time but the best result was after 72 h of treatments. Regarding Dill leaves and stems, cell numbers recorded no significant difference between the both on time dependent manner. Further investigation for ethanolic extracts of parsley leaves, fennel bulb, fennel stalks, celery stems, cilantro leaves and cilantro stems which showed better results than using the commercial drug Actinomycin D (25ml/ml) for 24 h treatment or less depending on concentrations manner. Also, further investigation on different types of cancer cell lines to avoid the toxic effect of chemotherapy.Keywords
This publication has 20 references indexed in Scilit:
- Global burden of cancers attributable to infections in 2012: a synthetic analysisThe Lancet. Global Health, 2016
- Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitroGene, 2015
- Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial ActivitiesPublished by Springer Science and Business Media LLC ,2015
- Coriander (Coriandrum sativum L.) and its bioactive constituentsFitoterapia, 2015
- Temozolomide may induce cell cycle arrest by interacting with URG4/URGCP in SH-SY5Y neuroblastoma cellsTumor Biology, 2015
- Cytotoxicity screening of essential oils in cancer cell linesRevista Brasileira de Farmacognosia, 2015
- Evaluating Medicinal Plants for Anticancer ActivityThe Scientific World Journal, 2014
- Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migrationBMC Complementary and Alternative Medicine, 2013
- Chromosomal and proteome analysis of a new T24‐based cell line model for aggressive bladder cancerProteomics, 2009
- Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci developmentCancer Letters, 2005