Antithrombin III in the prevention of thrombotic complications in high risk patients undergoing liver transplantation
- 14 September 2019
- journal article
- Published by IPO Association of Transplantologists in Transplantologiya
Abstract
Introduction. Recent studies have indicated an increased incidence of thrombotic vascular complications after liver transplantation. The reasons may be associated with surgical technique and “unbalanced” hemostasis in patients with diffuse liver diseases. The imbalance is determined by the deficiency of physiological procoagulants and anticoagulants due to a reduced protein-synthesis function of the liver in chronic hepatocyte injury. At the same time, 90% of all spontaneous antithrombin activity is associated with antithrombin III.Aim. The aim of the study was to evaluate the efficacy of using antithrombin III concentrate in liver transplant patients.Material and methods. A retrospective study included 46 patients undergoing liver transplantation who had nonocclusive thrombosis in the portal vein system prior to surgery and postoperative venous or arterial thrombosis.Results. The treatment results were compared between the group with antithrombin III concentrate and the control group in patients with portal vein thrombosis before surgery and postoperative venous or arterial thrombosis; the antithrombin III activity dynamics in the early postoperative period was assessed; the incidence of infectious, and vascular complications and the mortality rates were analyzed.Conclusion. The antithrombin III concentrate administration during liver transplantation and in the postoperative period contributes to a rapid normalization of antithrombin III activity in blood, the decrease in mortality and in the incidence of infectious and thrombotic complication rates.Keywords
This publication has 15 references indexed in Scilit:
- The System of Blood Coagulation in Normal and in Liver Transplantation (Review)General Reanimatology, 2018
- Experience with the use of antithrombin III concentrate in a multidisciplinary clinicAnnals of Critical Care, 2018
- The risk of venous thromboembolism in patients with cirrhosisThrombosis and Haemostasis, 2017
- Pathogenesis, prevention, and management of bleeding and thrombosis in patients with liver diseasesResearch and Practice in Thrombosis and Haemostasis, 2017
- Etiology and management of hepatic artery thrombosis after adult liver transplantationLiver Transplantation, 2014
- Treatment of Early Hepatic Artery Thrombosis After Liver TransplantationTransplantation Proceedings, 2011
- Systematic review: portal vein thrombosis in cirrhosisAlimentary Pharmacology & Therapeutics, 2010
- An Imbalance of Pro- vs Anti-Coagulation Factors in Plasma From Patients With CirrhosisGastroenterology, 2009
- Early Hepatic Artery Thrombosis after Liver Transplantation: A Systematic Review of the Incidence, Outcome and Risk FactorsAmerican Journal of Transplantation, 2009
- Hepatic artery thrombosis after orthotopic liver transplantation: A review of nonsurgical causesLiver Transplantation, 2001