The role of the subgenual anterior cingulate cortex in dorsomedial prefrontal–amygdala neural circuitry during positive‐social emotion regulation
Open Access
- 20 April 2020
- journal article
- research article
- Published by Wiley in Human Brain Mapping
- Vol. 41 (11), 3100-3118
- https://doi.org/10.1002/hbm.25001
Abstract
Positive‐social emotions mediate one's cognitive performance, mood, well‐being, and social bonds, and represent a critical variable within therapeutic settings. It has been shown that the upregulation of positive emotions in social situations is associated with increased top‐down signals that stem from the prefrontal cortices (PFC) which modulate bottom‐up emotional responses in the amygdala. However, it remains unclear if positive‐social emotion upregulation of the amygdala occurs directly through the dorsomedial PFC (dmPFC) or indirectly linking the bilateral amygdala with the dmPFC via the subgenual anterior cingulate cortex (sgACC), an area which typically serves as a gatekeeper between cognitive and emotion networks. We performed functional MRI (fMRI) experiments with and without effortful positive‐social emotion upregulation to demonstrate the functional architecture of a network involving the amygdala, the dmPFC, and the sgACC. We found that effortful positive‐social emotion upregulation was associated with an increase in top‐down connectivity from the dmPFC on the amygdala via both direct and indirect connections with the sgACC. Conversely, we found that emotion processes without effortful regulation increased network modulation by the sgACC and amygdala. We also found that more anxious individuals with a greater tendency to suppress emotions and intrusive thoughts, were likely to display decreased amygdala, dmPFC, and sgACC activity and stronger connectivity strength from the sgACC onto the left amygdala during effortful emotion upregulation. Analyzed brain network suggests a more general role of the sgACC in cognitive control and sheds light on neurobiological informed treatment interventions.Keywords
Funding Information
- H2020 European Research Council
- European Commission
- Baugarten Stiftung
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (P300PB_161083, 32003B_166566, 100014_178841, BSSG10_155915, PP00P2‐146318, PZ00P3‐131932)
This publication has 142 references indexed in Scilit:
- Connectivity-based neurofeedback: Dynamic causal modeling for real-time fMRINeuroImage, 2013
- Segregation of the human medial prefrontal cortex in social cognitionFrontiers in Human Neuroscience, 2013
- Reconsidering anhedonia in depression: Lessons from translational neuroscienceNeuroscience & Biobehavioral Reviews, 2011
- Modulation of subgenual anterior cingulate cortex activity with real‐time neurofeedbackHuman Brain Mapping, 2010
- Ten simple rules for dynamic causal modelingNeuroImage, 2009
- Guidelines for reporting an fMRI studyNeuroImage, 2008
- The Neural Bases of Emotion Regulation: Reappraisal and Suppression of Negative EmotionBiological Psychiatry, 2008
- Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and ThalamusBiological Psychiatry, 2007
- Optimized EPI for fMRI studies of the orbitofrontal cortex: compensation of susceptibility-induced gradients in the readout directionMagnetic Resonance Materials in Physics, Biology and Medicine, 2007
- Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdalaNeuroImage, 2007