National perinatal survey demonstrates a decreasing seroprevalence of Toxoplasma gondii infection among pregnant women in France, 1995 to 2016: impact for screening policy
Open Access
- 4 February 2021
- journal article
- research article
- Published by European Centre for Disease Control and Prevention (ECDC) in Eurosurveillance
- Vol. 26 (5), 1900710
- https://doi.org/10.2807/1560-7917.es.2021.26.5.1900710
Abstract
Background: Toxoplasmosis during pregnancy can result in congenital anomalies or fetal death. Universal antenatal screening is recommended in France, a strategy in place since the 1970s. Aim: We determined the seroprevalence of toxoplasmosis among pregnant women participating in the 2016 national perinatal survey (ENP), compared results with previous ENPs, and investigated factors associated with Toxoplasma gondii infection. Methods: Using the 2016 ENP data, which contain sociodemographic and clinical information from all women giving birth during a one week period, we calculated adjusted prevalence ratios (aPR) by sociodemographic factors. Using available data from prior ENPs (1995, 2003 and 2010), we calculated age-standardised seroprevalences and aPRs for French women. Results: In 2016, seroprevalence was 31.3% overall. Among French women, associations with increasing age (aPR: 1.54; 95% CI: 1.39–1.70), residence in Paris (aPR: 1.19; 95% CI: 1.08–1.31) or south-western regions (aPR: 1.19; 95% CI: 1.08–1.31), and higher professional status (aPR: 1.12; 95%CI 1.04–1.21) were observed. An association with increasing age was also evident among women from North Africa and sub-Saharan Africa. Age-standardised seroprevalence decreased from 55.0% in 1995 to 33.7% in 2016. Among French women, significant associations with age, Paris and south-west regions persisted across all ENPs. Conclusion: Higher prevalences in older women may reflect a higher past risk of exposure while persistent geographical differences may reflect dietary or environmental differences. Toxoplasma seroprevalence among pregnant women continues to fall and will impact screening effectiveness. This warrants a comprehensive review to determine the appropriate future of prevention in France.Keywords
This publication has 38 references indexed in Scilit:
- Activation of Nlrp3 Inflammasomes Enhances Macrophage Lipid-Deposition and Migration: Implication of a Novel Role of Inflammasome in AtherogenesisPLOS ONE, 2014
- Incidence and prevalence of Toxoplasma gondii infection in women in France, 1980–2020: model-based estimationEpidemiology and Infection, 2013
- Ranking the Disease Burden of 14 Pathogens in Food Sources in the United States Using Attribution Data from Outbreak Investigations and Expert ElicitationJournal of Food Protection, 2012
- Seroprevalence and risk factors for toxoplasmosis among antenatal women in London: a re-examination of risk in an ethnically diverse populationEuropean Journal of Public Health, 2012
- Disease burden of foodborne pathogens in the Netherlands, 2009International Journal of Food Microbiology, 2012
- A quantitative microbial risk assessment for meatborne Toxoplasma gondii infection in The NetherlandsInternational Journal of Food Microbiology, 2011
- Decreased prevalence and age-specific risk factors for Toxoplasma gondii IgG antibodies in The Netherlands between 1995/1996 and 2006/2007Epidemiology and Infection, 2010
- Effectiveness of health education on Toxoplasma-related knowledge, behaviour, and risk of seroconversion in pregnancyEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2008
- Severe Acquired Toxoplasmosis in Immunocompetent Adult Patients in French GuianaJournal of Clinical Microbiology, 2002
- Sources of toxoplasma infection in pregnant women: European multicentre case-control study Commentary: Congenital toxoplasmosis---further thought for foodBMJ, 2000