Iron-Catalyzed Direct Julia-Type Olefination of Alcohols
- 29 June 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 85 (15), 9876-9886
- https://doi.org/10.1021/acs.joc.0c01173
Abstract
Herein we report an iron-catalyzed, convenient and expedient strategy for the synthesis of styrene and naphthalene deriva-tives with the liberation of dihydrogen. The use of a catalyst derived from an earth-abundant metal provides a sustainable strategy to olefins. This method exhibits wide substrate scope (primary and secondary alcohols) functional group tolerance (amino, nitro, halo, alkoxy, thiomethoxy, and S- and N-heterocyclic compounds) and can be scaled up. The unprecedented synthesis of 1-methyl naphthalenes proceeds via tandem methenylation / double dehydrogenation. Mechanistic study shows that the cleavage of the C-H bond of alcohol is the rate determining step.Keywords
Funding Information
- University Grants Commission
- Science and Engineering Research Board (CRG/2018/002480)
- iiser tirupati
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