Botulinum Toxin in the Treatment of Headache
Open Access
- 17 December 2020
- Vol. 12 (12), 803
- https://doi.org/10.3390/toxins12120803
Abstract
Botulinum toxin type A has been used in the treatment of chronic migraine for over a decade and has become established as a well-tolerated option for the preventive therapy of chronic migraine. Ongoing research is gradually shedding light on its mechanism of action in migraine prevention. Given that its mechanism of action is quite different from that of the new monoclonal antibodies directed against calcitonin gene-related peptide (CGRP) or its receptor, it is unlikely to be displaced to any major extent by them. Both will likely remain as important tools for patients with chronic migraine and the clinicians assisting them. New types of botulinum toxin selective for sensory pain neurons may well be discovered or produced by recombinant DNA techniques in the coming decade, and this may greatly enhance its therapeutic usefulness. This review summarizes the evolution of botulinum toxin use in headache management over the past several decades and its role in the preventive treatment of chronic migraine and other headache disorders.Keywords
This publication has 63 references indexed in Scilit:
- Onabotulinum toxin A treatment of cervicogenic headache: A randomised, double-blind, placebo-controlled crossover studyCephalalgia, 2011
- Activation of central trigeminovascular neurons by cortical spreading depressionAnnals of Neurology, 2010
- Method of Injection of OnabotulinumtoxinA for Chronic Migraine: A Safe, Well‐Tolerated, and Effective Treatment Paradigm Based on the PREEMPT Clinical ProgramHeadache: The Journal of Head and Face Pain, 2010
- OnabotulinumtoxinA for treatment of chronic migraine: Results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trialCephalalgia, 2010
- OnabotulinumtoxinA for treatment of chronic migraine: Results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trialCephalalgia, 2010
- Botulinum Toxin Type A Prophylactic Treatment of Episodic Migraine: A Randomized, Double‐Blind, Placebo‐Controlled Exploratory StudyHeadache: The Journal of Head and Face Pain, 2006
- Botulinum Toxin Type A (BOTOX®) for the Prophylactic Treatment of Chronic Daily Headache: A Randomized, Double‐Blind, Placebo‐Controlled TrialHeadache: The Journal of Head and Face Pain, 2005
- Clinical results of botulinum toxin type a treatment of migraine headacheAesthetic Surgery Journal, 2002
- Botulinum toxin type A (BOTOX) for treatment of migraine headaches: An open-label studyOtolaryngology -- Head and Neck Surgery, 2000
- Botulinum Toxin Type A as a Migraine Preventive TreatmentHeadache: The Journal of Head and Face Pain, 2000