Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK
Open Access
- 8 March 2021
- journal article
- research article
- Published by Xia & He Publishing in Journal of Clinical and Translational Hepatology
- Vol. 000 (000), 000
- https://doi.org/10.14218/jcth.2021.00050
Abstract
Lipid accumulation is the major characteristic of non-alcoholic fatty liver disease, the prevalence of which continues to rise. We aimed to investigate the effects and mechanisms of icaritin on lipid accumulation.Keywords
This publication has 20 references indexed in Scilit:
- BODIPY staining, an alternative to the Nile Red fluorescence method for the evaluation of intracellular lipids in microalgaeBioresource Technology, 2012
- Autophagy: Renovation of Cells and TissuesCell, 2011
- Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expressionProceedings of the National Academy of Sciences of the United States of America, 2011
- Betanodavirus B2 Causes ATP Depletion-induced Cell Death via Mitochondrial Targeting and Complex II Inhibition in Vitro and in VivoOnline Journal of Public Health Informatics, 2010
- A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent mannerBone, 2009
- Lipid accumulation in non-adipose tissue and lipotoxicityPhysiology & Behavior, 2008
- A method for measuring mitochondrial mass and activityCytotechnology, 2008
- Autophagy in the Pathogenesis of DiseaseCell, 2008
- Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expressionDiabetes Research and Clinical Practice, 2006
- Treatment of non-alcoholic fatty liver diseaseHeart, 2006