The application of metagenomic next-generation sequencing in diagnosing Chlamydia psittaci pneumonia: a report of five cases
Open Access
- 17 March 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Pulmonary Medicine
- Vol. 20 (1), 1-7
- https://doi.org/10.1186/s12890-020-1098-x
Abstract
Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci. Diagnostic tools, including culture, serologic test and PCR-based methods, are available but prone to false negative results. This report included five cases of Chlamydia psittaci pneumonia. Symptoms and signs common to all 5 cases included fever, coughing, generalized muscle ache, and most notably, inflammatory infiltration of the lungs upon chest CT and X-ray. Metagenomic next-generation sequencing (mNGS) revealed the presence of Chlamydia psittaci in biopsy lung tissue in 3 cases and bronchoalveolar lavage fluid in the remaining 2 cases. Three patients responded to doxycycline plus moxifloxacin; two patients responded to moxifloxacin alone. mNGS could be used to diagnose Chlamydia psittaci pneumonia.Keywords
Funding Information
- National Key Clinical Specialty Discipline Construction Program of China (2015ZDZKHX)
This publication has 12 references indexed in Scilit:
- Disease burden of psittacosis in the NetherlandsEpidemiology and Infection, 2018
- Natural history of Mycobacterium fortuitum pulmonary infection presenting with migratory infiltrates: a case report with microbiological analysisBMC Infectious Diseases, 2018
- Chlamydia psittaci(psittacosis) as a cause of community-acquired pneumonia: a systematic review and meta-analysisEpidemiology and Infection, 2017
- Compendium of Measures to ControlChlamydia psittaciInfection Among Humans (Psittacosis) and Pet Birds (Avian Chlamydiosis), 2017Journal of Avian Medicine and Surgery, 2017
- Chlamydia–host cell interaction not only from a bird's eye view: some lessons from Chlamydia psittaciFEBS Letters, 2016
- Community-acquired pneumonia related to intracellular pathogensIntensive Care Medicine, 2016
- Clinical features of endemic community-acquired psittacosisNew Microbes and New Infections, 2014
- A case of acute psittacosis with severe abdominal painJournal of Medical Microbiology, 2011
- Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in AdultsClinical Infectious Diseases, 2007
- The use of serologic tests for the diagnosis of chlamydial infectionsJournal of Microbiological Methods, 2000