Cytotoxic tigliane diterpenoids from Euphorbia neorubella
- 7 May 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in Natural Product Research
- Vol. 36 (11), 2753-2757
- https://doi.org/10.1080/14786419.2021.1924712
Abstract
Two new tigliane diterpenes, named eupneonoids A (1) and B (2), together with four known analogues (3–6) were isolated from the whole plant of Euphorbia neorubella Bruyns. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates displayed cytotoxic effects against A549 human tumor cell lines with IC50 values ranging from 1.318 to 7.042 μM. Graphical AbstractKeywords
Funding Information
- National Natural Science Foundation of China (81803384)
- Natural Science Foundation of Jiangsu Province (BK20180947)
- Nantong Scientific Research Project (JC2019104)
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