The essential functions of mitochondrial dynamics in immune cells
- 10 June 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular & Molecular Immunology
- Vol. 17 (7), 712-721
- https://doi.org/10.1038/s41423-020-0480-1
Abstract
Mitochondria are highly mobile organelles due to fission, fusion, transport, and mitophagy, and these processes are known as mitochondrial dynamics. Mitochondrial dynamics play an important role in energy production, cell division, cell differentiation, and cell death. In the past decade, numerous studies have revealed the importance of mitochondrial metabolism in immunity, and mitochondrial dynamics are essential for immune responses mediated by various cell types. In this review, we mainly discuss the role of mitochondrial dynamics in activation, differentiation, cytokine production, and the activity of related pathways in immune cells, particularly T cells, B cells, and other cells involved in the innate immune response.Keywords
Funding Information
- National Natural Science Foundation of China (31822017, 81572651/ 81771675)
- Natural Science Foundation of Zhejiang Province (LR19C080001)
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