Renal cell carcinoma: a systematic review and meta-analysis on expression of androgen receptor
Open Access
- 5 November 2018
- journal article
- review article
- Published by Biomedical Research and Therapy in Biomedical Research and Therapy
- Vol. 5 (11), 2820-2826
- https://doi.org/10.15419/bmrat.v5i11.500
Abstract
Background: Chromosome Xq11-12 is the place that the androgen receptor (AR) sequence appears. Herein, the prevalence of this biomarker and its relation with pT stage and tumor grade was reported. Methods: Four online sites (PubMed, Scopus, Web of Science, and Cochrane Library) have been searched up to Sep 2018 systematically. Meta-Analysis software version 2.0 (CMA 2.0) and STATA 14.0 statistical software were utilized. Publication bias did not exist. Results: From the initial 1141 articles identified from the systematically searches. At last, nine of them remained for analysis. The meta-analysis included 1447 patients that 345 of them had AR expression. AR expression significantly correlated with low tumor grade and low tumor pT stage. Conclusion: AR expression was 28.2%, and it had the relationship with tumor low grade and low pT stage. Additional studies required to figure out the role of it on RCC patients.Keywords
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