A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis
Open Access
- 7 November 2020
- journal article
- research article
- Published by Elsevier BV in Acta Pharmaceutica Sinica. B
- Vol. 11 (3), 708-726
- https://doi.org/10.1016/j.apsb.2020.11.002
Abstract
No abstract availableKeywords
Funding Information
- National Natural Science Foundation of China (81973512, 81925034, 81701235, 81991514)
- China Pharmaceutical University (CPU2018GY06, CPU2018GY20)
- Fundamental Research Funds for the Central Universities (021414380446)
- Six Talent Peaks Project of Jiangsu Province
This publication has 66 references indexed in Scilit:
- Chromatin and beyond: the multitasking roles for SIRT6Trends in Biochemical Sciences, 2014
- Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemiaBiochemical and Biophysical Research Communications, 2013
- SIRT6 exhibits nucleosome-dependent deacetylase activityNucleic Acids Research, 2013
- SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysineNature, 2013
- Acute Cerebrovascular Disease in the YoungStroke, 2013
- EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesisCancer and Metastasis Reviews, 2012
- FOXC1, a target of polycomb, inhibits metastasis of breast cancer cellsBreast Cancer Research and Treatment, 2011
- FOXC1 Is a Potential Prognostic Biomarker with Functional Significance in Basal-like Breast CancerCancer Research, 2010
- Forkhead transcription factors in chronic inflammationThe International Journal of Biochemistry & Cell Biology, 2010
- FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1AHuman Molecular Genetics, 2007