Mediterranean is the birthplace of civilizational changes in world. There is special school of medicine in east of Islamic world which was formed by transferring Iranian medical heritage from ancient university of Jondishapur and medical sciences of India, Alexandria, Greece and Egypt. Therefore, Baghdad has arisen as a combined medical school. There is same school of medicine was established in west of Islamic world by evolutionary processes of Islamic medicine during its Mediterranean life and produced independent medical schools. Medical experience schools of ancient Cairo, Tunisia, Cordoba and Sicily transferred in Qairwan. This shows that medical development in Mediterranean world of Islamic period has been an increasing development, and Islamic medicine in the Mediterranean. Despite having Iranian roots and its origin go back to Avicenna, the founder of Islamic medicine and philosophy had a higher position than each other. It has acquired its oriental type. The medical school in the Mediterranean took place with the transfer of medicine from the first house of wisdom in the Islamic world to the second house of wisdom, which was built in Qairwan by Aghlabids state. The reality of Mediterranean period of Islamic medicine and its physical role in history of world medicine played by House of Wisdom (Beit al-Hakmeh ) Qairwan in the last stages of its development has prepared the collection of Islamic medical knowledge produced in Beit al-Hikma in Baghdad for final development by combining Latin teachings. By Transfer of Roman and Byzantine; medical knowledge from the Latin world to the Islamic world, which was a major milestone in the history of world medicine in southern Europe was made in Andalusia on the Iberian Peninsula, setting the stage for the latest evolution of medicine. A vast body of medical knowledge was transferred from North Africa and Andalusia to Europe (Salerno Italy) at the beginning of the European Renaissance.