Clinical profile and outcome of multisystem inflammatory syndrome in children and adolescents related to COVID-19 in a tertiary care hospital

Abstract

The pandemic of COVID-19 initially appeared to cause only a mild illness in children. The paediatric age group comprises only less than 7% of total COVID-19 worldwide. Multi system inflammatory syndrome in children (MIS-C) is a rare, but life-threatening complication of SARS-CoV-2 infection. We report a case series of 24 children with suspicion of multisystem inflammatory syndrome related to COVID-19 were assessed using diagnostic criteria established by ministry of health and family welfare, government of India using detailed history, clinical examination and relevant laboratory investigations. Among total 24 patients ranging from 23 days to 11 years with mean age of 4.5 years includes 10 patients (41.67%) presented with mild illness, 7 patients (29.12%) with persistent fever to Kawasaki disease (KD) like illness and 7 patients (29.12%) with fatal disease with MODS and shock. These children were managed as per guidelines with modifications for individual case if necessary and includes supportive management with main stays of IVIG and steroids. Three children died.