A molecular recognition-activatable DNA nanofirecracker enables signal-enhanced imaging in living cells
- 30 January 2020
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 56 (21), 3131-3134
- https://doi.org/10.1039/c9cc09682e
Abstract
We propose an aptamer-tethered DNA nanofirecracker probe that realizes molecular recognition-activatable disassembly of the DNA nanostructure for imaging of target molecules in living cells. The design principle offers a new paradigm to develop nucleic acid nanocircuits for live-cell study and manipulation.Keywords
Funding Information
- National Natural Science Foundation of China (21922404, 91753109, 21521063, 21505080, 2018JJ3034)
This publication has 20 references indexed in Scilit:
- Aflatoxin B1 Electrochemical Aptasensor Based on Tetrahedral DNA Nanostructures Functionalized Three Dimensionally Ordered Macroporous MoS2–AuNPs FilmACS Applied Materials & Interfaces, 2018
- A hybridization-chain-reaction-based method for amplifying immunosignalsNature Methods, 2018
- Simple multiplexed PCR-based barcoding of DNA for ultrasensitive mutation detection by next-generation sequencingNature Protocols, 2017
- Entropy Beacon: A Hairpin-Free DNA Amplification Strategy for Efficient Detection of Nucleic AcidsAnalytical Chemistry, 2015
- Toehold‐initiated Rolling Circle Amplification for Visualizing Individual MicroRNAs In Situ in Single CellsAngewandte Chemie, 2014
- Real-Time Detection of Isothermal Amplification Reactions with Thermostable Catalytic Hairpin AssemblyJournal of the American Chemical Society, 2013
- Dynamic DNA nanotechnology using strand-displacement reactionsNature Chemistry, 2011
- Measurement of single-cell dynamicsNature, 2010
- Enzyme-Free Nucleic Acid Logic CircuitsScience, 2006
- Triggered amplification by hybridization chain reactionProceedings of the National Academy of Sciences of the United States of America, 2004