Human population dynamics and Yersinia pestis in ancient northeast Asia
Open Access
- 8 January 2021
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 7 (2), eabc4587
- https://doi.org/10.1126/sciadv.abc4587
Abstract
We present genome-wide data from 40 individuals dating to c.16,900 to 550 years ago in northeast Asia. We describe hitherto unknown gene flow and admixture events in the region, revealing a complex population history. While populations east of Lake Baikal remained relatively stable from the Mesolithic to the Bronze Age, those from Yakutia and west of Lake Baikal witnessed major population transformations, from the Late Upper Paleolithic to the Neolithic, and during the Bronze Age, respectively. We further locate the Asian ancestors of Paleo-Inuits, using direct genetic evidence. Last, we report the most northeastern ancient occurrence of the plague-related bacterium, Yersinia pestis. Our findings indicate the highly connected and dynamic nature of northeast Asia populations throughout the Holocene.Keywords
Funding Information
- Knut and Alice Wallenberg Foundation
This publication has 98 references indexed in Scilit:
- mapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parametersBioinformatics, 2013
- DNA analysis of an early modern human from Tianyuan Cave, ChinaProceedings of the National Academy of Sciences of the United States of America, 2013
- Analysis of High-Throughput Ancient DNA Sequencing DataMethods in molecular biology (Clifton, N.J.), 2011
- The variant call format and VCFtoolsBioinformatics, 2011
- A framework for variation discovery and genotyping using next-generation DNA sequencing dataNature Genetics, 2011
- Ancient human genome sequence of an extinct Palaeo-EskimoNature, 2010
- A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotypeBioinformatics, 2009
- A Complete Neandertal Mitochondrial Genome Sequence Determined by High-Throughput SequencingCell, 2008
- PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage AnalysesAmerican Journal of Human Genetics, 2007
- Molecular basis of human hypertension: Role of angiotensinogenCell, 1992