Association of irritable bowel syndrome in patients with atrial fibrillation: a nationwide population-based investigation
- 1 November 2020
- journal article
- research article
- Published by SAGE Publications in Perfusion
- Vol. 35 (8), 847-852
- https://doi.org/10.1177/0267659120912363
Abstract
Objective: We seek to characterize the association between atrial fibrillation and irritable bowel syndrome. Methods: We identify 11,642 cases (atrial fibrillation) and 46,487 sex-, age-, and index year-matched controls (non-atrial fibrillation) from Longitudinal Health Insurance Database. Kaplan-Meier, Cox proportional hazards regression methods and competing risk analysis methods were used to assess the association of atrial fibrillation with outcome of irritable bowel syndrome. Results: After adjustment for gender, age, comorbidities and medications, patients with atrial fibrillation had a significant higher risk (adjusted hazard ratio = 1.12, p < 0.01) to develop irritable bowel syndrome than patients without atrial fibrillation. Compared to participants without atrial fibrillation, those with atrial fibrillation had 1.13-fold (p < 0.05) and 1.11-fold (p < 0.05) risk of irritable bowel syndrome in female and male subgroup, respectively. Among subjects aged >= 65 years, those with AF had 1.11-fold risk of irritable bowel syndrome than non-AF cohort (P < 0.01). Among participants with any one of the comorbidities, those with atrial fibrillation had 1.10-fold risk of irritable bowel syndrome than non-atrial fibrillation cohort (p < 0.05). Conclusion: We report that the presence of atrial fibrillation is associated with greater incidence of irritable bowel syndrome and the association is stronger among female gender, age 65 years or above, and with comorbidities.This publication has 20 references indexed in Scilit:
- Validity of in-hospital mortality data among patients with acute myocardial infarction or stroke in National Health Insurance Research Database in TaiwanInternational Journal of Cardiology, 2015
- Autonomic nervous system dysregulation in irritable bowel syndromeNeurogastroenterology & Motility, 2015
- Gastrointestinal comorbidities associated with atrial fibrillationSpringerPlus, 2014
- Role of the Autonomic Nervous System in Atrial FibrillationCirculation Research, 2014
- Validation of Acute Myocardial Infarction Cases in the National Health Insurance Research Database in TaiwanJournal of Epidemiology, 2014
- Global Burden of Atrial Fibrillation in Developed and Developing NationsCVD Prevention and Control, 2014
- The role of oxidants and reactive nitrogen species in irritable bowel syndrome: A potential etiological explanationMedical Science Monitor, 2013
- Validation of the national health insurance research database with ischemic stroke cases in TaiwanPharmacoepidemiology and Drug Safety, 2010
- Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimatesThe American Journal of Cardiology, 1998
- Impact of Atrial Fibrillation on the Risk of DeathCirculation, 1998