Elevated preoperative neutrophil‐to‐lymphocyte ratio predicts early adverse outcomes in uncomplicated type B aortic dissection undergoing TEVAR
Open Access
- 16 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Cardiovascular Disorders
- Vol. 21 (1), 1-9
- https://doi.org/10.1186/s12872-021-01904-y
Abstract
Thoracic aortic endovascular repair (TEVAR) of uncomplicated type B aortic dissection (uTBAD) has favorable long-term outcomes but higher early adverse events compared with the optimal medical treatment. Recently, clinical evidence concerning vascular surgery indicates that elevated preoperative systemic inflammatory response predicts adverse clinical events. The aim of our study was to evaluate the relationship between preoperative neutrophil-to-lymphocyte ratio (NLR) and early outcomes of uTBAD patients undergoing TEVAR. 216 patients diagnosed with uTBAD were included in this retrospective study between January 2015 and December 2018. The median (IQR) follow-up period was 21 (15–33) months. An early adverse event was defined as occurring within 2 years after the procedure. Median patient age was 60 (IQR, 48–68) years and 78.7 % were male. Early adverse events occurred in 24 patients (11.1 %). In the multivariable analysis, preoperative NLR (HR per SD, 1.98; 95 % CI, 1.14–3.44; P = 0.015) was associated with 2-year adverse events. NLR is an independent predictive factor of early adverse events in uTBAD patients undergoing TEVAR.Keywords
Funding Information
- National Natural Science Foundation of China (81700430, 9173910048)
- National Natural Science Foundation of China (81700430, 9173910048)
This publication has 40 references indexed in Scilit:
- Prognostic Value of Neutrophil to Lymphocyte Ratio in Patients Presenting With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary InterventionThe American Journal of Cardiology, 2013
- Neutrophil to lymphocyte ratio and cardiovascular diseases: a reviewExpert Review of Cardiovascular Therapy, 2013
- Neutrophil-Lymphocyte Ratio Predicts Medium-Term Survival Following Elective Major Vascular Surgery: A Cross-Sectional StudyVascular and Endovascular Surgery, 2011
- Importance of Refractory Pain and Hypertension in Acute Type B Aortic DissectionCirculation, 2010
- Inflammation and immune response in acute aortic dissectionAnnals of Medicine, 2010
- Usefulness of Neutrophil to Lymphocyte Ratio in Predicting Short- and Long-Term Mortality After Non–ST-Elevation Myocardial InfarctionThe American Journal of Cardiology, 2010
- Detection of inflammation in patients with acute aortic syndrome: comparison of FDG-PET/CT imaging and serological markers of inflammationHeart, 2008
- Partial Thrombosis of the False Lumen in Patients with Acute Type B Aortic DissectionThe New England Journal of Medicine, 2007
- Simple Risk Models to Predict Surgical Mortality in Acute Type A Aortic Dissection: The International Registry of Acute Aortic Dissection ScoreThe Annals of Thoracic Surgery, 2007
- Plasma Levels of Soluble Tumor Necrosis Factor Receptor Type I During the Acute Phase Following Complicated Myocardial Infarction Predicts Survival in High-Risk PatientsJournal of the American College of Cardiology, 2005