Effects of Environmental and Pathological Hypoxia on Male Fertility
Open Access
- 13 September 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cell and Developmental Biology
Abstract
Male infertility is a widespread health problem affecting approximately 6%–8% of the male population, and hypoxia may be a causative factor. In mammals, two types of hypoxia are known, including environmental and pathological hypoxia. Studies looking at the effects of hypoxia on male infertility have linked both types of hypoxia to poor sperm quality and pregnancy outcomes. Hypoxia damages testicular seminiferous tubule directly, leading to the disorder of seminiferous epithelium and shedding of spermatogenic cells. Hypoxia can also disrupt the balance between oxidative phosphorylation and glycolysis of spermatogenic cells, resulting in impaired self-renewal and differentiation of spermatogonia, and failure of meiosis. In addition, hypoxia disrupts the secretion of reproductive hormones, causing spermatogenic arrest and erectile dysfunction. The possible mechanisms involved in hypoxia on male reproductive toxicity mainly include excessive ROS mediated oxidative stress, HIF-1α mediated germ cell apoptosis and proliferation inhibition, systematic inflammation and epigenetic changes. In this review, we discuss the correlations between hypoxia and male infertility based on epidemiological, clinical and animal studies and enumerate the hypoxic factors causing male infertility in detail. Demonstration of the causal association between hypoxia and male infertility will provide more options for the treatment of male infertilityKeywords
This publication has 238 references indexed in Scilit:
- Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudesAsian Journal of Andrology, 2013
- Hypoxia-Inducible Factors in Physiology and MedicineCell, 2012
- Altitude can alter the mtDNA copy number and nDNA integrity in spermJournal of Assisted Reproduction and Genetics, 2011
- Hypoxia-Inducible Factors and the Response to Hypoxic StressMolecular Cell, 2010
- Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stressMolecular and Cellular Endocrinology, 2010
- Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and Premature EjaculationEuropean Urology, 2010
- Male germ cell apoptosis: regulation and biologyPhilosophical Transactions B, 2010
- NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1αNature, 2008
- Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activityProceedings of the National Academy of Sciences of the United States of America, 2006
- Dating the rise of atmospheric oxygenNature, 2004