Synthesis of Deuterated (E)-Alkene through Xanthate-Mediated Hydrogen–Deuterium Exchange Reactions
- 9 September 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 23 (19), 7412-7417
- https://doi.org/10.1021/acs.orglett.1c02600
Abstract
Herein we have developed a reversible hydrogen-deuterium exchange reaction of nonactivated olefins. By using EtOCS2K as a mediator, the H/D exchange reaction was realized through repeated addition and elimination reactions, demonstrating reversible H/D exchange between ordinary olefins and deuterated olefins. Using the lowest cost D2O without precious metal catalysts and ligands, a broad spectrum of compatibility of functional groups was achieved.Keywords
Funding Information
- Department of Education of Guangdong Province (2018KZDXM070, 2019KZDXM052, 2021KTSCX140)
- College Students Innovation and Entrepreneurship Training Program (2019cx01, 2020cx26, S2020211349091)
- Science Foundation for Young Teachers of Wuyi University (2019td06)
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