Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model
Open Access
- 6 July 2021
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 118 (28)
- https://doi.org/10.1073/pnas.2105245118
Abstract
Understanding the potential of nanomaterials (NMs) to cross the blood–brain barrier (BBB), as a function of their physicochemical properties and subsequent behavior, fate, and adverse effect beyond that point, is vital for evaluating the neurological effects arising from their unintentional entry into the brain, which is yet to be fully explored. This is not only due to the complex nature of the brain but also the existing analytical limitations for characterization and quantification of NMs in the complex brain environment. By using a fit-for-purpose analytical workflow and an in vitro BBB model, we show that the physiochemical properties of metallic NMs influence their biotransformation in biological matrices, which in turn modulates the transport form, efficiency, amounts, and pathways of NMs through the BBB and, consequently, their neurotoxicity. The data presented here will support in silico modeling and prediction of the neurotoxicity of NMs and facilitate the tailored design of safe NMs.Keywords
This publication has 40 references indexed in Scilit:
- Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitromodels of the rat blood-brain barrier and blood-spinal cord barrierBMC Neuroscience, 2013
- Biotransformation of Ceria Nanoparticles in Cucumber PlantsACS Nano, 2012
- Guest Comment: Transformations of Nanomaterials in the Environment Focus IssueEnvironmental Science & Technology, 2012
- Derivation of blood-brain barrier endothelial cells from human pluripotent stem cellsNature Biotechnology, 2012
- Transformations of Nanomaterials in the EnvironmentEnvironmental Science & Technology, 2012
- Surface Defects on Plate-Shaped Silver Nanoparticles Contribute to Its Hazard Potential in a Fish Gill Cell Line and Zebrafish EmbryosACS Nano, 2012
- Internal benchmarking of a human blood–brain barrier cell model for screening of nanoparticle uptake and transcytosisEuropean Journal of Pharmaceutics and Biopharmaceutics, 2011
- Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimagingParticle and Fibre Toxicology, 2010
- Human astrocytes/astrocyte-conditioned medium and shear stress enhance the barrier properties of human brain microvascular endothelial cellsBrain Research, 2007
- Apolipoprotein-mediated Transport of Nanoparticle-bound Drugs Across the Blood-Brain BarrierJournal of Drug Targeting, 2002