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Role of nipple discharge cytology in predicting NAC involvement in carcinoma breast

Sumanashree Mallappa, Nimisha Sharma, Arti Khatri, Vimal Bhandari
Published: 28 May 2017
Annals of Woman and Child Health , Volume 3; doi:10.21276/AWCH.1543

Abstract: IntroductionCancer of the breast in women is a major health burden worldwide. It is the most common cause of cancer among women in both high-resource and low-resource settings, and is responsible for over one million of the estimated 10 million neoplasms diagnosed worldwide each year in both sexes. Limited number of studies have addressed the optimal surgical management of patients with breast carcinoma associated with benign or pathologic nipple dischargeMaterial and methods-Thirteen breast carcinoma cases with nipple discharge were studied. Nipple discharge cytology was studied using giemsa method. Later all the mastectomy specimens were inked and sectioned from medial to lateral into no greater than 1 cm thick tissue sections and grossly examined. Extensive sampling of nipple areola was followed taking 12 sections from each nipple areolar complex.Thirteen breast carcinoma cases without nipple discharge were chosen as control and also grossed and examined for nipple areolar involvement .Results-In our study, there were 13 cases with nipple discharge. Out of which, 10 cases were having benign cytologic findings and 3 cases showed malignant cytologic findingsSpss statistical software was used which showed no association between presence of nipple discharge and nipple areolar involvement also it showed no association between malignant nipple discharge cytologic findings and nipple areolar involvement.Conclusions-Nipple discharge itself has no association with nipple areolar involvement and should not deter a clinician from nipple sparing mastectomy if other factors are conducive. Careful patient selection can be done in cases with malignant nipple discharge cytologic findings, if negative margins could be achieved and appropriate adjuvant therapy given.Further studies are needed to study the role of nipple discharge cytology in conservative mastectomy procedures.DOI: 10.21276/AWCH.1543
Keywords: breast carcinoma / Conservative Mastectomy / Nipple Areolar Complex / Nipple Discharge Cytology

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