Abstract
In this issue of Nephron, Perico, Benigni, and Remuzzi offer a concise overview of the interactions of the SARS-CoV-2 virus, the angiotensin-converting enzyme (ACE) pathway(s), and the cell surface glycoprotein ACE2, and describe the mechanism of cellular SARS-CoV-2 uptake via the endocytosis-lysosomal pathway [1].