Cost–effectiveness analysis of empagliflozin compared with glimepiride in patients with Type 2 diabetes in China
Open Access
- 1 April 2021
- journal article
- research article
- Published by Becaris Publishing Limited in Journal of Comparative Effectiveness Research
- Vol. 10 (6), 469-480
- https://doi.org/10.2217/cer-2020-0284
Abstract
Aim: The study assesses the cost–effectiveness of empagliflozin versus glimepiride in patients with Type 2 diabetes and uncontrolled by metformin alone in China, based on the EMPA-REG H2H-SU trial. Materials & methods: A calibrated version of the IQVIA Core Diabetes Model was used. Cost of complications and utility were taken from literature. The Chinese healthcare system perspective and 5% discounting rates were applied. Results: Empagliflozin+metformin provides additional quality-adjusted life-years (0.317) driven by a reduction in the number of cardiovascular and renal events, for an additional cost of $1382 (CNY9703) compared with glimepiride+metformin. Conclusion: Empagliflozin is cost-effective treatment versus glimepiride applying a threshold of $30,290 (CNY212,676).Keywords
This publication has 28 references indexed in Scilit:
- COST-UTILITY ANALYSIS OF LIRAGLUTIDE VERSUS GLIMEPIRIDE AS ADD-ON TO METFORMIN IN TYPE 2 DIABETES PATIENTS IN CHINAInternational Journal of Technology Assessment in Health Care, 2012
- An analysis of early insulin glargine added to metformin with or without sulfonylurea: impact on glycaemic control and hypoglycaemiaDiabetes, Obesity and Metabolism, 2011
- An Australian cardiovascular risk equation for type 2 diabetes: the Fremantle Diabetes StudyInternal Medicine Journal, 2010
- Risk Prediction of Cardiovascular Disease in Type 2 DiabetesDiabetes Care, 2008
- Cost-effectiveness of switching to biphasic insulin aspart in poorly-controlled type 2 diabetes patients in ChinaAdvances in Therapy, 2008
- Cost-Utility Analysis of Intensive Blood Glucose Control with Metformin versus Usual Care in Overweight Type 2 Diabetes Mellitus Patients in Beijing, P.R. ChinaValue in Health, 2008
- Modelling EuroQol health‐related utility values for diabetic complications from CODE‐2 dataHealth Economics, 2004
- Prediction of Coronary Heart Disease in Middle-Aged Adults With DiabetesDiabetes Care, 2003
- Simple Scoring Scheme for Calculating the Risk of Acute Coronary Events Based on the 10-Year Follow-Up of the Prospective Cardiovascular Münster (PROCAM) StudyCirculation, 2002
- Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)The Lancet, 1998