Fragment‐Bindung an die Kinase‐Scharnier‐Region: Wenn Ladungsverteilung und lokale pKa‐Verschiebungen etablierte Bioisosterie‐Konzepte fehlleiten
Open Access
- 6 October 2020
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 133 (1), 256-262
- https://doi.org/10.1002/ange.202011295
Abstract
No abstract availableThis publication has 32 references indexed in Scilit:
- Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug DesignJournal of Medicinal Chemistry, 2020
- Fragment-to-Lead Medicinal Chemistry Publications in 2018Journal of Medicinal Chemistry, 2020
- RCSB Protein Data Bank: Sustaining a living digital data resource that enables breakthroughs in scientific research and biomedical educationProtein Science, 2018
- Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitorsBioorganic & Medicinal Chemistry Letters, 2016
- Molecular Docking and Structure-Based Drug Design StrategiesMolecules, 2015
- An analysis of the attrition of drug candidates from four major pharmaceutical companiesNature Reviews Drug Discovery, 2015
- Comparative Performance of Several Flexible Docking Programs and Scoring Functions: Enrichment Studies for a Diverse Set of Pharmaceutically Relevant TargetsJournal of Chemical Information and Modeling, 2007
- Hit discovery and hit-to-lead approachesDrug Discovery Today, 2006
- Bioisosterism: A Useful Strategy for Molecular Modification and Drug DesignCurrent Medicinal Chemistry, 2005
- Bioisosterism: A Rational Approach in Drug DesignChemical Reviews, 1996