Parkinson’s Disease and Impairment in Mitochondrial Metabolism: A Pathognomic Signature
- 17 March 2021
- book chapter
- research article
- Published by Springer Science and Business Media LLC
- Vol. 1286, 65-76
- https://doi.org/10.1007/978-3-030-55035-6_4
Abstract
Mitochondrial bioenergetics is vital for the proper functioning of cellular compartments. Impairments in mitochondrial DNA encoding the respiratory chain complexes and other assisting proteins, accumulation of intracellular reactive oxygen species, an imbalance in cellular calcium transport, or the presence of organic pollutants, high fat-ketogenic diets or toxins, and advancing age can result in complex disorders, including cancer, metabolic disease, and neurodegenerative disorders. Such manifestations are distinctly exhibited in several age-related neurodegenerative diseases, such as in Parkinson’s disease (PD). Defects in complex I along with perturbed signaling pathways is a common manifestation of PD. Impaired oxidative phosphorylation could increase the susceptibility to PD. Therefore, unraveling the mechanisms of mitochondrial complexes in clinical scenarios will assist in developing potential early biomarkers and standard tests for energy failure diagnosis and assist to pave a new path for targeted therapeutics against PD.Keywords
This publication has 76 references indexed in Scilit:
- Regulation of ATP production by mitochondrial Ca2+Cell Calcium, 2012
- Toxin Models of Mitochondrial Dysfunction in Parkinson's DiseaseAntioxidants and Redox Signaling, 2012
- The Role of Environmental Exposures in Neurodegeneration and Neurodegenerative DiseasesToxicological Sciences, 2011
- Epidemiology and etiology of Parkinson’s disease: a review of the evidenceEuropean Journal of Epidemiology, 2011
- Epigenetics, oxidative stress, and Alzheimer diseaseFree Radical Biology & Medicine, 2009
- Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease BrainOnline Journal of Public Health Informatics, 2008
- Mitochondria Are a Major Source of Paraquat-induced Reactive Oxygen Species Production in the BrainOnline Journal of Public Health Informatics, 2007
- Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brainPhysiological Genomics, 2007
- Iron, brain ageing and neurodegenerative disordersNature Reviews Neuroscience, 2004
- Mitochondrial oxidative phosphorylation defects in Parkinson's diseaseAnnals of Neurology, 1992