Volumetric MRI-guided, high-intensity focused ultrasound ablation of uterine leiomyomas: ASEAN preliminary experience
- 1 May 2020
- journal article
- research article
- Published by Galenos Yayinevi in Diagnostic and Interventional Radiology
- Vol. 26 (3), 207-215
- https://doi.org/10.5152/dir.2019.19157
Abstract
PURPOSE We sought to present our preliminary experience on the effectiveness and safety of magnetic resonance imaging (MRI)-guided, high-intensity focused ultrasound (HIFU) therapy using a volumetric ablation technique in the treatment of Association of Asian Nations (ASEAN) patients with symptomatic uterine leiomyomas. METHODS This study included 33 women who underwent HIFU treatment. Tissue characteristics of leiomyomas were assessed based on T2- and T1-weighted MRI. The immediate nonperfused volume (NPV) ratio and the treatment effectiveness of MRI-guided HIFU on the basis of the degrees of volume reduction and improvement in transformed symptom severity score (SSS) were assessed. RESULTS The median immediate NPV ratio was 89.8%. Additionally, the median acoustic sonication power and HIFU treatment durations were 150 W and 125 min, respectively. At six-month follow-up, the median leiomyoma volume had decreased from 139 mL at baseline to 84 mL and the median transformed SSS had decreased from 56.2 at baseline to 18.8. No major adverse events were observed. CONCLUSION The preliminary results demonstrated that volumetric MRI-guided HIFU therapy for the treatment of symptomatic leiomyomas in ASEAN patients appears to be clinically acceptable with regard to treatment effectiveness and safety.This publication has 21 references indexed in Scilit:
- Mid-term clinical efficacy of a volumetric magnetic resonance-guided high-intensity focused ultrasound technique for treatment of symptomatic uterine fibroidsEuropean Radiology, 2013
- Volumetric MR-guided High-Intensity Focused Ultrasound Ablation with a One-Layer Strategy to Treat Large Uterine Fibroids: Initial Clinical OutcomesRadiology, 2012
- Clinical 24 month experience of the first MRgFUS Unit for treatment of uterine fibroids in AustraliaJournal of Medical Imaging and Radiation Oncology, 2012
- Leiomyoma Shrinkage After MRI-Guided Focused Ultrasound Treatment: Report of 80 PatientsAmerican Journal of Roentgenology, 2010
- Clinical outcomes of magnetic resonance‐guided focused ultrasound surgery for uterine myomas: 24‐month follow‐upUltrasound in Obstetrics & Gynecology, 2009
- Volumetric HIFU ablation under 3D guidance of rapid MRI thermometryMedical Physics, 2009
- Fibroids and infertility: an updated systematic review of the evidenceFertility and Sterility, 2009
- Uterine Leiomyomas: MR Imaging–guided Focused Ultrasound Surgery—Imaging Predictors of SuccessRadiology, 2008
- Mid-term outcome of magnetic resonance-guided focused ultrasound surgery for uterine myomas: From six to twelve months after volume reductionJournal of Minimally Invasive Gynecology, 2007
- Uterine Leiomyomas: MR Imaging–guided Focused Ultrasound Surgery—Results of Different Treatment Protocols1Radiology, 2007