Associations between Environmental dust composition and Atopic Dermatitis in urban and rural settings
- 17 February 2021
- journal article
- research article
- Published by Wiley in Pediatric Allergy and Immunology
- Vol. 32 (5), 1013-1021
- https://doi.org/10.1111/pai.13476
Abstract
Background Environmental exposures are involved in the pathogenesis of the allergic phenotype, and in determining which individual triggers a person becomes sensitized to. Atopic dermatitis (AD) may modulate these effects through increased penetration through the skin modifying the immune system and AD may be triggered or intensified by environmental exposures. These exposures and immune‐modulating factors may differ in urban and rural environments. Objectives To compare house dust composition in urban and rural settings and correlate them with AD outcomes. Methods Dust samples were collected from the beds of 156 children aged 6 months to 3 years. 42% of participants had atopic dermatitis. Samples were analysed for bacterial endotoxin, fungal (β‐1,3‐glucan) levels, and house dust mite, cockroach, dog, cat, mouse and peanut allergen. Exposures were compared in urban and rural environments, and in participants with and without AD. Results Endotoxin but not fungal β‐glucan exposure is higher in the environment of healthy controls than children with AD in both urban and rural settings. House dust mite allergen exposure is high in urban and rural settings with Dermatophagoides detected in 100% of samples. Cat and dog allergen exposure mirrors pet ownership patterns which differ slightly between groups and environments. Mouse allergen exposure is higher in urban homes. Conclusion Environmental endotoxin may be protective against AD in both urban and rural settings. There are marked differences in allergen exposure in urban and rural settings, but these are unlikely to be important protective or risk factors.Keywords
Funding Information
- Robert Bosch Stiftung
- South African Medical Research Council
This publication has 23 references indexed in Scilit:
- Ethnic differences in peanut allergy patterns in South African children with atopic dermatitisPediatric Allergy and Immunology, 2015
- Prevalence of Blomia tropicalis allergy in two regions of South AfricaSouth African Medical Journal, 2015
- Farm environment during infancy and lung function at the age of 31: a prospective birth cohort study in FinlandBMJ Open, 2015
- Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergyJournal of Allergy and Clinical Immunology, 2014
- Peanut allergy: Effect of environmental peanut exposure in children with filaggrin loss-of-function mutationsJournal of Allergy and Clinical Immunology, 2014
- Food allergy in South African children with atopic dermatitisPediatric Allergy and Immunology, 2014
- Guidelines of care for the management of atopic dermatitisJournal of the American Academy of Dermatology, 2013
- Levels of Environmental Endotoxin and Prevalence of Atopic DiseaseJAMA, 2000
- House dust mite allergy in Southern Africa — historical perspective and current statusClinical & Experimental Allergy, 1996
- Hay fever, hygiene, and household size.BMJ, 1989