Establishment and validation of an eight-gene metabolic–related prognostic signature model for lung adenocarcinoma
Open Access
- 22 February 2021
- journal article
- research article
- Published by Impact Journals, LLC in Aging
- Vol. 13 (6), 8688-8705
- https://doi.org/10.18632/aging.202681
Abstract
In this study, we constructed an eight-gene metabolic related signature for LUAD. The eight-gene prognostic signature (including PLAUR, F2, UGT2B17, GNG7, IDO2, ST3GAL6, PIK3CG, and GLS2) exhibited a good prognostic value in the TCGA LUAD training dataset and testing dataset. In addition, the risk score based on the signature model was significantly correlated with immune cell infiltration and expression levels of immune markers in LUAD patients. LUAD cohorts from GEO were used to validate the model, indicating the usefulness of the model. In summary, we developed and validated an eight-gene signature model for LUAD, which can reflect the immune microenvironment characteristics and predict the prognostic outcomes for LUAD patients.Keywords
This publication has 39 references indexed in Scilit:
- GSVA: gene set variation analysis for microarray and RNA-Seq dataBMC Bioinformatics, 2013
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene ClustersOMICS: A Journal of Integrative Biology, 2012
- Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cellsNature Immunology, 2011
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissuesGlycobiology, 2010
- Autophagy and MetabolismScience, 2010
- Prognostic gene signatures for non-small-cell lung cancerProceedings of the National Academy of Sciences of the United States of America, 2009
- Survival prediction of stage I lung adenocarcinomas by expression of 10 genesJCI Insight, 2007
- GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductorBioinformatics, 2007
- A Five-Gene Signature and Clinical Outcome in Non–Small-Cell Lung CancerThe New England Journal of Medicine, 2007