Astrocytic Regulation of Neural Circuits Underlying Behaviors
Open Access
- 1 February 2021
- Vol. 10 (2), 296
- https://doi.org/10.3390/cells10020296
Abstract
Astrocytes, characterized by a satellite-like morphology, are the most abundant type of glia in the central nervous system. Their main functions have been thought to be limited to providing homeostatic support for neurons, but recent studies have revealed that astrocytes actually actively interact with local neural circuits and play a crucial role in information processing and generating physiological and behavioral responses. Here, we review the emerging roles of astrocytes in many brain regions, particularly by focusing on intracellular changes in astrocytes and their interactions with neurons at the molecular and neural circuit levels.Keywords
Funding Information
- The Brain Research Program through the National Research Foundation of Korea, funded by the Ministry of Science and ICT, South Korea (2016M3C7A1947307, 2016M3C7A1904148, 2020R1A6A1A03040516)
This publication has 165 references indexed in Scilit:
- Cumulative lesioning of respiratory interneurons disrupts and precludes motor rhythms in vitroProceedings of the National Academy of Sciences of the United States of America, 2012
- Heterogeneity of Astrocytic Form and FunctionMethods in Molecular Biology, 2011
- AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without trainingNature Neuroscience, 2011
- Genetic dissection of an amygdala microcircuit that gates conditioned fearNature, 2010
- Specific disruption of astrocytic Ca2+ signaling pathway in vivo by adeno-associated viral transductionNeuroscience, 2010
- Roles for nigrostriatal—not just mesocorticolimbic—dopamine in reward and addictionTrends in Neurosciences, 2009
- Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injuryProceedings of the National Academy of Sciences of the United States of America, 2009
- Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like BehaviorsBiological Psychiatry, 2008
- Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligandProceedings of the National Academy of Sciences of the United States of America, 2007
- A novel multigene family may encode odorant receptors: A molecular basis for odor recognitionCell, 1991